Nothing major struck me in this letter (except the description of the fire, which others have already commented on), but I did notice several little things.
Le Faye comments that JA must have been joking when she wished her brother joy of completing his thirtieth year, because he was actually turning 41!
Also, I wondered if she was entirely serious about the chimney being "in such a state as to make it wonderful that it should have stood so long, and next to impossible that another violent wind should not blow it down". Was it really that bad, or were the masons exaggerating to make the fees they charged seem worth it?
The fact that Mrs. Austen was picking apart her old pelisse to use for mourning reminds me that this household had to be careful of its money.
I also noticed that they had brewed spruce beer in honour of Martha's arrival. I seem to remember Julie W. saying that she had tried it once and didn't like it because it was so piney!
I wonder what was wrong with JA's ear that she couldn't hear?
Near the end, JA commented that "(Lady Bridges) is a *nice* woman and honours me by her remembrance". I didn't think they used "nice" in our modern sense yet in JA's day, meaning kind or likeable.